Vanadate-induced expression by hypoxia inducible factor-1.ALPHA. via oxygen-dependent and -independent pathways
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概要
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Increase in hypoxia-inducible factor-1<I>α</I> (HIF-1<I>α</I>) expression is caused by some essential trace elements such as vanadium and cobalt even under normoxic conditions. The mechanism of HIF-1<I>α</I> activation caused by vanadium is not documented well whereas several authors proposed that by cobalt. When HEK293 cells were treated with 100 <I>μ</I>M sodium orthovanadate, HIF-1<I>α</I> expression increased within 6 to 12 hours. The increase was suppressed by HIF-1<I>α</I>-specific inhibitors, YC-1 for the metal-related oxygen sensing pathway, and 17-AAG for the Hsp90-dependent pathway. The results suggest that orthovanadate increases HIF-1<I>α</I> expression via both oxygen-dependent and -independent pathways.
- 日本微量元素学会の論文
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