Age-Related Changes in Blood Pressure, Heart Rate and Heart Rate Variability in Healthy Beagle Dogs
スポンサーリンク
概要
- 論文の詳細を見る
Objective—The circadian rhythms of blood pressure (BP), heart rate (HR) and heart rate variability (HRV) in aged dogs are important considerations in the prescription of cardiovascular agents, especially antihypertensives. However, currently there are limited data in the literature concerning this topic. Therefore, this study determined the circadian rhythms of BP, HR and HRV in aged dogs and compared the data to those of young dogs.Procedure—Healthy female beagles were assigned to the "aged group" (10-11 y; n=5) or "young group" (1-3 y; n=6). The systolic BP (SBP), Diastolic BP (DBP), pulse pressure (PP) and HR were continuously recorded in non-anesthetized and unrestrained dogs over seven days using a telemetry system. The high-frequency (HF) and low-frequency/high-frequency (LF/HF) data of HR variability (HRV) were also determined.Results—In the aged group, the circadian rhythms of SBP, DBP, HR and LF/HF were bimodal, while HF was unimodal. In the young group, the circadian rhythms of HR and LF/HF were bimodal and SBP, DBP and HF were unimodal. The amplitudes of the circadian rhythms of PP were small in both groups. A unique finding in the aged group was that the average value of SBP rose (p=0.0002) and that of DBP fell (p<0.0001), resulting in a significant increase in the value of PP (p<0.0001). There were no significant differences in the average values of HR and HF in the groups. The average values of LF/HF were significantly higher in the young group (p<0.0001).Conclusion—The findings of this study suggest that the circadian rhythms of cardiac parameters in aged dogs are different from those of young dogs. Aged dogs' variations may be more easily affected by environmental stimulations such as feeding. Additionally, in aged dogs, PP increased significantly. The observed rise in SBP and fall in DBP in the aged dogs is similar to the changes observed in humans.
- 日本獣医循環器学会の論文
日本獣医循環器学会 | 論文
- ヒトの特発性心筋症の遺伝子解析
- 遺伝子診断法
- 部分内臓逆位, 肝部後大静脈欠損および奇静脈連結を伴う静脈管開存症の犬の1例
- 右前大静脈欠損を伴う左前大静脈遺残の犬の一例
- 長期観察が可能であった猫拡張型心筋症の1例