Clastogenic Effects of the Fasciolicides Closantel and Nitroxynil on Mice Somatic and Germ Cells
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Salicylanilide (Closantel) and halogenated phenol (Nitroxynil) have been reported to be an active fasciolocidal agents used in human and in farm animals. The clastogenic effects of Closantel at 5, 10, 15, 20 mg kg−1 b.wt. and Nitroxynil at 10, 20, 30, 40 mg kg−1 b.wt. were tested in mice somatic and germ cells through 3 cytogenetic parameters. Chromosomal aberrations, sister-chromatid exchanges and sperm-shape abnormalities. The results demonstrated that, after intraperitoneal (i.p.) injector with a single doses for 24 h. Closantel and Nitroxynil induced different types of structural chromosomal aberrations in bone-marrow cells which increased significantly with different doses. The frequencies of SCEs were increased significantly with Closantel compared to Nitroxynil induced non-significant frequencies of SCEs except at high dose (40 mg kg−1 b.wt.). The percentage of chromosomal aberrations in diakinesis-metaphase I spermatocytes increased in a dose dependent manner and were found to be statistically significant with the 2 drugs. The 2 fasciolicides induced a signifycant percentage of sperm-shape abnormalities. The highest doses induced 12.74±0.49 and 7.02±0.13 (p<0.01) for closantel and nitroxynil respectively, compared to the control. In conclusion, the 3 cytogenetic parameters used to evaluate the effect of Closantel and Nitroxynil revealed that the 2 fasciolicides have a clastogenic effect on mice somatic and germ cells in vivo studies.
- 財団法人 日本メンデル協会の論文
財団法人 日本メンデル協会 | 論文
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