Consistently greater decondensation of the nuclear DNA-protein complexes from normal lymphocytes than from acute and chronic lymphocytic leukemia cells following treatment with disulfide reducing agents.
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Nuclear DNA-protein complexes (DPC's) obtained by lysis of lymphocytes with nonionic detergents in the presence of varying concentrations of NaCl showed readily visualized decondensations following treatment with S-S reducing agents. Magnitudes of these decondensations were significantly greater with lymphocytes from normal individuals compared to acute or chronic lymphocytic leukemia cells from every patient tested. Control experiments indicated that decondensations occurred not through DNA strand breakage or indirect action, but most likely through reduction of S-S bonds present in DPC's. This alteration of DPC structure in leukemic cells may relate to their potentially unlimited proliferative lifespan and altered genomic regulation.
- 財団法人 日本メンデル協会の論文
財団法人 日本メンデル協会 | 論文
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