Central Injection of Endomorphin-2, but not Endomorphin-1, Increases Food Intake in Chicks via .MU.1-opioid Receptors
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概要
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The endogenous tetrapeptides endomorphin-1 and -2 are potent, selective μ-opioid receptor agonists in mammals. The present study was done to elucidate whether central injection of endomorphins enhances feeding behavior in chicks, and to investigate the interaction with the μ<SUB>1</SUB>-opioid receptor. We found that the intracerebroventricular injection of endomorphin-2 (10-30nmol) significantly stimulated food intake in neonatal chicks during the 60-min period postinjection. However, the same doses of endomorphin-1 injected with ICV had no significant effects on feeding behavior. The orexigenic effect of endomorphin-2 was significantly attenuated by the μ<SUB>1</SUB>-opioid receptor antagonist naloxonazine. These results indicate that the administration of endomorphin-2, but not endomorphin-1, into the chick brain produces the orexigenic effect through the μ<SUB>1</SUB>-opioid receptor.
- 日本家禽学会の論文
日本家禽学会 | 論文
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