The Role of Renal Natriuretic and Depressor Systems in Insulin-Resistant Hypertensive Rats
スポンサーリンク
概要
- 論文の詳細を見る
<B>Insulin resistance and impairment of the renal depressor system have been thought to be involved in the development of essential hypertension. However, the relationship between insulin resistance and this system is still unclear. To clarify this relationship, we investigated the role of the renal depressor system in a rat model of insulin-resistant hypertension. Sprague-Dawley rats were fed a standard diet (control) or a fructose-rich diet (FFR), and their blood pressures were measured every week. Urinary dopamine (uDA), urinary kallikrein (uKAL) activity and urinary nitric oxide (uNO<SUB><I>x</I></SUB>) levels were also measured each week, and the renal mRNA expression levels of endothelial nitric oxide synthase (eNOS), aromatic-L-amino-acid decarboxylase (AADC), and kallikrein (KAL) activity were compared at the end of the study. The blood pressure of FFR was elevated significantly from 2 weeks after the start of fructose loading. The uDA level was lower in FFR than in control rats throughout the study period (<I>p</I> <0.01), and the expression level of AADC mRNA was enhanced in FFR (<I>p</I> <0.05). There was a tendency of negative correlation between uDA level and systolic blood pressure (SBP) (<I>r</I> =-0.49, <I>p</I> =0.056). uNO<SUB><I>x</I></SUB> level was lower in FFR throughout the study period (<I>p</I> <0.05), and the eNOS mRNA expression level in the kidney was lower in FFR than in control rats (<I>p</I> <0.05). There was a negative correlation between uNO<SUB><I>x</I></SUB> level and SBP (<I>r</I> =-0.68, <I>p</I> <0.01). On the other hand, there was no significant difference in the kallikrein-kinin system between FFR and control rats. In conclusion, impairment in functions of the renal dopamine and NO systems occur in FFR, and this impairment may be caused by insulin resistance and may contribute to the development of hypertension. (<I>Hypertens Res</I> 2004; 27: 501-508)</B>
- 日本高血圧学会の論文
日本高血圧学会 | 論文
- Telmisartan treatment decreases Visceral Fat Accumulation and improves Serum Levels of Adiponectin and Vascular Inflammation Markers in Japanese Hypertensive Patients.
- The Effects of Verapamil SR and Bisoprolol on Reducing the Sympathetic Nervous System's Activity.
- The Role of Renal Dopamine in the Reduction of High Blood Pressure by β1-Selective β-Blocker with Intrinsic Sympathomimetic Activity in Spontaneously Hypertensive Rats
- Effects of Long-Term Antihypertensive Therapy on Physical Fitness of Men with Mild Hypertension.
- Prediction of Progression of Left Ventricular Hypertrophy in Mild Hypertension: 5-Year Observations without Pharmacological Intervention.