Effects of a Low Dose of Indapamide, a Diuretic, Given Daily or Every-Other-Day on Blood Pressure and Metabolic Parameters
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<B>To investigate the effects of the diuretic, indapamide, on blood pressure (BP) and metabolic parameters, thirty hypertensive patients were treated with 1 mg of indapamide either every day or every other day. BP, fasting plasma glucose, lipids, serum potassium and uric acid were determined at baseline and after 3 months of a stable regimen of the drug. At the termination of the study, 48-h ambulatory blood pressure monitoring (ABPM) was performed. Three patients received only indapamide, while other patients were treated in combination with additional antihypertensive medications. Patients treated with daily indapamide showed a BP reduction from 162±2.9/85±2.4 mmHg to 134±2.4/71±2.6 mmHg (<I>p</I> <0.001). The BP reduction was similar in those patients receiving the drug every other day (137±3.4/71±3.6 mmHg). While plasma lipids and serum potassium did not differ significantly with the intervention, uric acid increased significantly with daily treatment and normalized with every-other-day treatment. Glycosylated hemoglobin A<SUB>1c</SUB> (HbA<SUB>1c</SUB>) was not altered (5.6±0.1% <I>vs</I>. 5.4±0.2%), and did not differ between patients with and without diabetes mellitus. ABPM revealed an average 24-h BP of 134±3.3/75±1.7 mmHg on days in which patients received the medication and 139±4.9/78±2.6 mmHg on the intervening day without indapamide (no significant difference). These results suggest that a low dose of indapamide given every day or every other day is effective in lowering BP and does not result in metabolic derangements. (<I>Hypertens Res</I> 2004; 27: 141-145)</B>
- 日本高血圧学会の論文
日本高血圧学会 | 論文
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