CYP11B2 Polymorphisms and Home Blood Pressure in a Population-Based Cohort in Japanese: the Ohasama Study
スポンサーリンク
概要
- 論文の詳細を見る
<B>Genetic polymorphisms of the aldosterone synthase gene (<I>CYP11B2</I>) have been major targets of studies into the genetic factors involved in hypertension. We have identified three genetic variants of <I>CYP11B2</I>, -344C/T at the promoter region, a conversion in intron 2 from the <I>CYP11B2</I> sequence to the <I>CYP11B1</I> sequence, and R173K in exon 3, in the Japanese population. -344C/T and R173K were in complete linkage disequilibrium in <I>CYP11B2</I>, and -344C/T was in strong, but not complete, linkage disequilibrium with the polymorphism in intron 2. Thus, two genetic polymorphisms, -344C/T and the gene conversion in intron 2, were investigated in association with home blood pressure (BP) values and clinical parameters in 1,242 subjects aged 40 and over in Ohasama, a rural Japanese community. Hypertension was defined as being treated with antihypertensive medication and/or having home BP values of more than 135 mmHg in systole and/or 85 mmHg in diastole. The results demonstrated that the -344T allele was significantly associated with increased prevalence of hypertension (<I>p</I> =0.015 in multiple logistic regression analysis, adjusted by age, gender, BMI, and smoking status), though BP level was unaltered. This allele was also significantly related to the prevalence of cardiovascular diseases in the older population (60 ≤ age, <I>p</I> =0.014). The resting polymorphism, a gene conversion in <I>CYP11B2</I> intron 2, was not associated with any clinical parameters. Therefore, -344C/T polymorphism in <I>CYP11B2</I> was considered an independent genetic factor possibly associated with hypertension or atherosclerotic diseases in the Japanese population. (<I>Hypertens Res</I> 2004; 27: 1-6)</B>
- 日本高血圧学会の論文
日本高血圧学会 | 論文
- Telmisartan treatment decreases Visceral Fat Accumulation and improves Serum Levels of Adiponectin and Vascular Inflammation Markers in Japanese Hypertensive Patients.
- The Effects of Verapamil SR and Bisoprolol on Reducing the Sympathetic Nervous System's Activity.
- The Role of Renal Dopamine in the Reduction of High Blood Pressure by β1-Selective β-Blocker with Intrinsic Sympathomimetic Activity in Spontaneously Hypertensive Rats
- Effects of Long-Term Antihypertensive Therapy on Physical Fitness of Men with Mild Hypertension.
- Prediction of Progression of Left Ventricular Hypertrophy in Mild Hypertension: 5-Year Observations without Pharmacological Intervention.