A1166C Polymorphism of the Angiotensin II Type 1 Receptor Gene and Essential Hypertension in Han, Tibetan and Yi Populations.
スポンサーリンク
概要
- 論文の詳細を見る
<B>Our aim was to clarify whether substitution of cytosine for adenine at position 1166 (A1166C) polymorphism of the angiotensin II type 1 receptor (AT<SUB>1</SUB>R) gene is associated with susceptibility to essential hypertension in Han, Tibetan and Yi populations in China. This study involved 302 normotensive and 446 hypertensive subjects. The polymorphism was detected by polymelase chain reaction of genomic DNA and restriction fragment length polymorphism (PCR-RFLP) in genomic DNA. The data were analyzed by analysis of covariance (ANCOVA), Χ<SUP>2</SUP> test, and multiple logistic regression. In normotensive controls, the A1166 allele frequencies were 0.979, 0.939 and 0.965 in Han, Tibetan and Yi participants, respectively. There was no significant intergroup variation in frequency of the allele in normotensives (Χ<SUP>2</SUP> =4.166, <I>p</I> =0.125). The frequency of the A1166 allele was significantly higher in Tibetan male hypertensives than that in normotensives (Χ<SUP>2</SUP> =11.46, <I>p</I> =0.001). There was no significant difference in A1166C genotype distribution and allele frequency between normotensives and hypertensives either in the Han (<I>p</I> =0.465) or Yi (<I>p</I> =0.357) populations. Body mass index in the Han and Yi populations (<I>p</I> =0.0001), age in the Tibetan and Yi populations (<I>p</I> =0.0001), and AA genotype in the Tibetan male population (<I>p</I> =0.0034) all were independent risk factors for hypertension. Diastolic blood pressure levels were significantly higher in Tibetan male subjects with the AA genotype than in those with the AC+CC genotype (<I>p</I> =0.0040). We concluded that the A1166 allele is very common in Han, Tibetan and Yi populations, approximately 1.35-fold more common than in Caucasians. The A1166 allele of the AT<SUB>1</SUB>R gene may be a predisposing factor for essential hypertension in Tibetan males. A1166C polymorphism of the AT<SUB>1</SUB>R gene is probably not involved in the pathogenesis of essential hypertension in Han or Yi populations. (<I>Hypertens Res</I> 2002; 25: 515-521)</B>
- 日本高血圧学会の論文
日本高血圧学会 | 論文
- Telmisartan treatment decreases Visceral Fat Accumulation and improves Serum Levels of Adiponectin and Vascular Inflammation Markers in Japanese Hypertensive Patients.
- The Effects of Verapamil SR and Bisoprolol on Reducing the Sympathetic Nervous System's Activity.
- The Role of Renal Dopamine in the Reduction of High Blood Pressure by β1-Selective β-Blocker with Intrinsic Sympathomimetic Activity in Spontaneously Hypertensive Rats
- Effects of Long-Term Antihypertensive Therapy on Physical Fitness of Men with Mild Hypertension.
- Prediction of Progression of Left Ventricular Hypertrophy in Mild Hypertension: 5-Year Observations without Pharmacological Intervention.