Association of a Mast Cell Chymase Gene Variant with HDL Cholesterol, but not with Blood Pressure in the Ohasama Study.
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<B>Two enzymes, chymase and angiotensin converting enzyme (ACE), are involved in the production of angiotensin II. Our previous study revealed the male-specific effect of the <I>ACE DD</I> genotype on the risk for hypertension, but the genetic role of chymase remains unclear. In the present study, we report the results of an association study involving 1, 046 subjects recruited from a general population in Ohasama, a rural community in the northern part of Japan. In addition to casual blood pressure (casual BP) measurement, home BP measurements were obtained from all participants. There were no differences in either home or casual BP values according to <I>G3255A</I> polymorphism of the mast cell chymase gene (<I>MCC</I>). HDL cholesterol level was significantly higher among carriers of the <I>A3255</I> allele (<I>p</I><0.04). After adjustment for confounding factors, the <I>A3255</I> allele was still shown to have an effect on HDL cholesterol metabolism (<I>p</I><0.03). Multiple regression analysis showed that MCC polymorphism was significantly and independently related to serum HDL cholesterol level. In conclusion, <I>G3255A</I> polymorphism of <I>MCC</I> is not directly associated with blood pressure but may modulate the prevalence of hypertensive complications <I>via</I> alteration of lipid metabolism. (<I>Hypertens Res</I> 2002; 25: 179-184)</B>
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