Improvement in Cardiac Function and Free Fatty Acid Metabolism in a Case of Dilated Cardiomyopathy With CD36 Deficiency
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概要
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A 27-year-old man diagnosed as having dilated cardiomyopathy (DCM) without myocardial accumulation of <SUP>123</SUP>I-β-methyl-iodophenylpentadecanoic acid, and he was found to have type I CD36 deficiency. This abnormality of cardiac free fatty acid metabolism was also confirmed by other methods: <SUP>18</SUP>F-fluoro-2-deoxyglucose positron emission tomography, measurements of myocardial respiratory quotient and cardiac fatty acid uptake. Although the type I CD36 deficiency was reconfirmed after 3 months, the abnormal free fatty acid metabolism improved after carvedilol therapy and was accompanied by improved cardiac function. Apart from a cause-and-effect relationship, carvedilol can improve cardiac function and increase free fatty acid metabolism in patients with both DCM and CD36 deficiency.
- 社団法人 日本循環器学会の論文
社団法人 日本循環器学会 | 論文
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