Effects of α1-Adrenoreceptor Subtype Blockade on Ischemia-Reperfusion Injury
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To clarify the roles of subclasses of α1-adrenoreceptors in ischemic-reperfused myocardium, we compared the effect of the nonselective α1-blocker bunazosin with that of the α1A-blocker WB4101 and the α1B-blocker chlorethylclonidine (CEC) in isolated rat hearts. After 30 min of preperfusion, Langendorff-perfused hearts were subjected to 25 min of global ischemia followed by 30 min of reperfusion. Hearts were randomly divided into 4 groups, with one of the following substances being added to the perfusate: buffer alone (control), 10-6 mol/L bunazosin, 10-7 mol/L WB4101, or 10-7 mol/L CEC. Bunazosin had a negative inotropic effect and preserved the postischemic ATP content, reduced the postischemic increase in intracellular Na+ content and then enhanced postreperfusion recovery of creatine phosphate. Bunazosin also reduced myocardial 45Ca2+ uptake during reperfusion (control 5.2 vs bunazosin 2.5 μmol/g dry weight of tissue (dwt), p<0.01). However, the recovery of left ventricular developed pressure (DP) was not improved when bunazosin was added to the perfusate during reperfusion. WB4101 had neither a negative inotropic nor an energy-sparing effect, but it improved the recovery of DP (control 43% vs WB4101 56% of preischemic value, p<0.05) with no reduction in myocardial 45Ca2+ uptake. CEC had a negative inotropic and energy-sparing effect and then reduced myocardial 45Ca2+ uptake (CEC 3.1 μmol/g dwt, p<0.05), but it did not improve the recovery of DP. These results suggest that the preischemic administration of an α1B-adrenoreceptor subtype blocker protected ischemic-reperfused myocardium via reduction of Ca2+ overload, whereas the selective blockade of the α1A-adrenoreceptor subtype reduced myocardial damage via mechanism(s) other than Ca2+ metabolism. (Jpn Circ J 1997; 61: 927 - 935)
- 社団法人 日本循環器学会の論文
社団法人 日本循環器学会 | 論文
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