Azurin–DNA Conjugate with the Binding Motif of a Transcriptional Regulator, CooA: CO-dependent Modulation of the Electron-transfer Reaction

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概要

• 論文の詳細を見る

• An azurin–DNA conjugate (Azu–DNA) where the DNA part contains the binding sequence of a carbon monoxide (CO)-dependent transcriptional regulator, CooA, has been prepared. CooA in the CO-bound form (CO–CooA) showed specific binding to Azu–DNA. The association of CO–CooA with Azu–DNA affects the electron transfer (ET) between Azu–DNA and its redox partner protein, cytochrome c552. Consequently, the CO-dependent modulation of ET was achieved. This could be a potential platform for a novel biobased sensor, which exploits the transcriptional regulator as a detection module and whose readout is immediately transduced to a readily processable electronic signal.

• 公益社団法人 日本化学会の論文

著者

• NAKAJIMA Hiroshi

  Graduate Student, University of Tsukuba(presently Mitsubishi Heavy Industry).

• Watanabe Yoshihito

  Research Centre of Materials Science, Nagoya University

• Miyazaki Soji

  Research Centre of Materials Science, Nagoya University

• Itoh Takaaki

  Graduate School of Science, Nagoya University

• Hayamura Mao

  Graduate School of Science, Nagoya University

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• Azurin–DNA Conjugate with the Binding Motif of a Transcriptional Regulator, CooA: CO-dependent Modulation of the Electron-transfer Reaction

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