アレビアチン(癲癇抑制剤)による口腔内病変
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概要
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Six patients, treated by aleviatin for the purpose of anticonvulsion, were otorhinologically investigated.<BR>There were five cases of gingival swelling while there was no changes in ear, nose, or larynx. In severe case, mastication could not be performed. Generally this symptom appeared after a year, of internal administration, but it is not always be in parallel with administered dose. In the young, the teeth set was remarkably zigzag. The swelling was not so remarkable in the case of lacking tooth. The horizontal and vertical resorption was roentgenologically observed. Histological examination showed the horny change of the uppermost layer and the proliferation of basal cell layer. Connective tissue cells contained generally collagen fiber and ware edematous, so-called papillomatous proliferation being observed.
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