オフロキサシン耳用液の内耳に及ぼす影響に関する実験的研究
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概要
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It is imperative to establish the effect of a newly developed otic solution upon the inner ear before its clinical application because some kinds of otic solutions may induce sensorineural hearing loss. In the present study, the authors evaluated the influence of Ofloxacin (OFLX) upon the inner ear. Using guinea pigs of the Hartley strain, 24 animals were subjected to a left myringotomy and then divied into three groups. The 10 animals of group (A) were administered 0.3% OFLX otic solution in the middle ear cavity, the 9 animals of group (B) similarly received 0.5% OFLX, and the remaining 5 animals of group (C) received a control solvent only. The solutions were administered continuously for 7 days. The auditory brainstem response (ABR) of all test and control animals was measured both before administration of otic solution and on the 10 th day after final adminisration with a stimulation of 10, 000 Hz using Teledyne Avionics 1000. Finally, the auditory structures were fixed by a method of intravital perfusion and the cochlea were examined pathohistologically. Results indicated no significant difference in ABR recording before and after the examination. Microscopic examination revealed no evidence of damage to the Organ of Corti nor any degeneration of the hair cells in any animals of groups A, B, and C. In conclusion, under the experimental conditions described, OFLX otic solution exerts no discernable adverse effects upon inner ear.
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