Cefamandoleの滲出性中耳炎貯留液への移行について

概要

論文の詳細を見る
Chronic otitis media with effusion (OME) has generally been charactarized as an otitis media without bacterial infection. A recent study has shown that bacteria (especialy H. influenzae and S. pneumoniae) are of major importance in the pathogenesis of chronic OME. We examined antimicrobial therapy in the treatment of OME. The penetration of Cefamandole (CMD) into Middle ear effusion (MEE) was studied and compared with serum levels. Patients with chronic OME aged 4 to 8 years received a single dose of 1000mg CMD by the venous route 15 minutes to 70 minutes before the removal of MEE and insertion of tympanostomy tubes. The penetration and elimination of CMD into MEE was very rapid and paralleled the serum levels.
耳鼻と臨床会の論文