神奈川7大学におけるシスプラチンの使用経験

概要

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Clinical effect of Cisplatin were evaluated in 55 patients with head and neck malignancies at 7 University clinics in Kanagawa prefecture. As a whole, the responsive rate was 55.5% for head and neck tumor. But the complete response could not be observed in any case. No difference of the effectiveness were not detected among the different primary regions, such as the larynx, hypopharynx and maxillary sinus. Also there was no significant difference by the differenciate grade of the squamous cell carcinoma, which is the most popular histological finding in head and neck carcinoma. Otherwhile, it was considered that the effectiveness of Cisplatin had a characteristic of the dose dependent. Furthermore, the response rate of the Cisplatin administration with other drugs was higher than those of the single use. Especially, the multidisciplinaly treatment combining the neo-ajuvant or induction chemotherapy is useful for head and neck carcinoma.
耳鼻と臨床会の論文