制癌剤の副作用に対するCoenzyme Q10の予防効果

概要

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The clinical effects of coenzyme Q10 (CoQ10) against the side effects induced by anti-cancer drugs were investigated in 409 patients who have head and neck cancer, from April in 1977 to March in 1983. The investigated side effects were abnormalities of ECG and pulmonary function insufficiency which were mortal to patient's life. Coenzyme Q10 (CoQ10), isolated from the electron transfer system in the mitochondria, has been reported to produce favorable protective and restorative effects on myocardium caused by ischemia or by cardiotoxic drugs such as adriamycin (ADM) in both clinical and experimental studies. Result: Using the anthracycline anti-cancer drugs, adriamycin (59 cases), acracinomycin (32 cases), abnomalities of ECG were demonstrated to be in lower incidence than control group which has been reported already on the other hand pulmonary function insufficiency, reversible lung fibrosis which were induced by Peplomycin appe ared in only 1.6% (5cases).
耳鼻と臨床会の論文