頭頸部悪性腫瘍におけるCyclophosphamide (C), Adriamycin (A), Cis-Platinumdiamminedichloride (P) による併用療法の検討

概要

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A combined chemotherapy with Cyclophosphamide (CPM), Adriamycin (ADM) and Cis-Platinumdiamminedichloride (CPDD) was performed on ten patients with advanced, recurrent or metastatic head and neck malignant tumors, and the therapeutic of were investigated. CPM at a dose of 300mg/m2, ADM at a dose of 30mg/m2 and CPDD at a dose of 40mg/m2 were administrated intravenously or intraarterially in one day after hydration of the patient. Of ten cases, one case had a complete response and two cases had a partial response, thus the response rate was 30%. In view of histological findings, therapeutic effects were observed in anaplastic carcinoma and adenocarcinoma, while no effects was observed on squamous cell carcinoma which had already been treated by radiotherapy and surgery. Two cases which had a low performance status were treated effectively with One-Day CAP regimen. The therapy was less effective in cases with a high performance status. Toxic effects associated with combined chemotherapy were nausea, vomiting, leucopenia, anemia and fever. However, the symptomes were temporary and they were not severe. These results lead to the following conclusion: One-day CAP therapy is useful for anaplastic carcinoma and adenocarcinoma, and also it is useful as a neo-adjuvant chemotherapy prior to surgery and/or radiotherapy.
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