鼻副鼻腔Papillomaの蛋白分解酵素活性

概要

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It has been shown that the exogenous protease transformed the normal cells in vitro, and the endogenous proteases and plasminogen activator have been closely related to the transformation of various cells. In otorhinolaryngological field, we be lieved that the cells of laryngeal and paranasal papilloma were mostly composed of virally transformed cells. In order to clarify the relationship between the tissue of the papilloma and the proteolytic activity, we examined the fibrinolytic activity, caseinolytic activity and esterolytic activity in the papilloma tissue in comparison with the noninflammatory, inflammatory paranasal mucous membrane and antrochoanal polyp. The results obtained were as follows:<BR>1) The tissue extract of papilloma contained a small amount of plasminogen activator and a large amount of SK-reactive activator. But the caseinolytic activity was not detected in the tissue extract.<BR>2) The high esterolytic activity was observed in the tissue extract of papilloma and it was equivalent to that observed in the tissue extract of the inflammatory paranasal mucous membrane.<BR>From these results it was suggested that the fibrinolytic activity of papilloma was equivalent to that of antrochoanal polyp and nasal polyp, and the proliferative characteristics of papilloma cell might depend upon its fibrinolytic activity, that is, the activity of SK-reactive activator.
耳鼻と臨床会の論文