ヒト上顎癌腫細胞培養の試み:ヌードマウス移植による腫瘍形成

概要

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Suspension-type cultured cells (MC cells) derived in our laboratory in 1976 from human carcinoma of the maxillary sinus (squamous cell carcinoma) were transfered to five congenitally athymic mouse mutants,"nude", at doses of 10<SUP>7</SUP> cells. Tumor formation was found locally at the site of inoculation within 10 days in every case with no distant metastases. The tumors grew rapidly and constantly and continued to grow until death (within 39 days) of the hosts. Histopathological examination of the transplanted tumors revealed the proliferation of malignant cells and shows similarity to that of the human donor material. It could be concluded, therefore, that the cultured cell, used in our study, is a established cell line of human carcinoma of the maxillary sinus.
耳鼻と臨床会の論文