イノシトールヘキサニコチネート (クレバミン) の血中に於ける持続性について
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概要
- 論文の詳細を見る
Nicotinic acid is an excellent vasodilator, but the durability of vasodilatic effect of it is very short. Recently, inositol hexanicotinate, a new durable nicotinic acid derivative, was synthesized. And usually this drug has been used for therapeutic purposes. But, the reports about the durability of this drug in blood are very rare and there is no report which compares the durability with that of the old nicotinic acid or some other derivatives.<BR>In the experiments with rabbits, the author measured the concentration of nicotinic acid in blood after the administration of inositol hexanicotinate, and compared it with the concentration of nicotinic acid in blood after the administration of it.<BR>The results of the experiments are as follows: in inositol hexanicotinate administrated to rabbits, the concentration of nicotinic acid in blood came to the maximum 3 hours after it. In nicotinic acid administrated to rabbits, the concentration of it came to the maximum 1 hour later, and 3 hours afterwards it recovered itself to the normal degree. Compared with nicotinic acid, the author concluded that inositol hexanicotinate is an excellent durable vasodilator.
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