An Evaluation of the Cerebral Hemodynamics in Moyamoya Disease with Acetazolamide (Diamox) 99mTc-HMPAO SPECT.
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<I>We studied the cerebral hemodynamics using Diamox</I> <SUP>99m</SUP>Tc-<I>HMPAO SPECT in 9 patients with Moyamoya disease, consisting 4 children and 5 adults. Diamox</I> <SUP>99m</SUP>Tc-<I>HMPAO SPECT studies were performed by the double injection method. Hypoperfusion areas were scored by a visual inspection as follows: ++; definite positive, +; probable positive, -; negative. Diamox test was interpreted as positive when the score increased over one degree. In the resting state, 6 out of 9 patients showed definite or probable positive hypoperfusion, while all of 9 patients showed a similar finding after Diamox injection. The Diamox test was positive in 6 out of 9 patients. It was positive in all 3 patients who showed a negative hypoperfusion in the resting state. The regional cerebrovascular response to Diamox was most severely impaired in the frontal region. However, it was relatively well preserved in the cerebellum and thalamus according to the semiquantitative analysis. Thus, the Diamox HMPAO SPECT was considered to be useful in evaluating of the hemodynamics in patients with Moyamoya disease</I>.
- 社団法人 日本アイソトープ協会の論文
社団法人 日本アイソトープ協会 | 論文
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