Distribution model for the intact urokinase and urokinases modified by soluble macromolecules in rat and mouse bodies.
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概要
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<I>The activity of intact urokinase (UK) and urokinases modified by soluble macromolecules (dextran and dextran sulfate sodium) in a mouse body was traced after injection of the <SUP>125</SUP>I labelled enzymes. The residual fraction of the enzyme in blood can be correlated with the time (t) as follows; </I><BR><I>Xb=Ae<SUP>-at</SUP>+Be<SUP>-bt</SUP>+Ce<SUP>-ct</SUP></I><BR><I>Since a>b>c, the residual fraction of the enzyme in blood chiefly depends on the magnitude of parameter C. The constant C for modified urokinase was larger than that for urokinase, showing the relative residual in blood was increased by modification of the enzyme. The apparent utilization in 50 min was 13.8% for intact UK, 28.1 % for the dextran- UK and 25.2% for the sulfate dextran-UK. Therefore, the apparent utilization of UK in blood was approximately doubled by the modification. Since the half-lives of UK and modified UK in kidney and liver were not long, there were no unacceptable accumulation of the enzymes.</I>
- 社団法人 日本アイソトープ協会の論文
社団法人 日本アイソトープ協会 | 論文
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