Syntheses of (prolyl-U-14C)alacepril and its related compounds.
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概要
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<I>In order to study the metabolic fate of alacepril, an anti-hypertensive agent, the</I> <SUP>14</SUP>C-<I>labeled compound of alacepril and its related compounds were synthesized</I>.<BR><I> [Prolyl-U-<SUP>14</SUP>C] alacepril was synthesized in over-all yield of 32.7-38. 0% by the mixed anhydride condensation of</I> L <I>phenylalanine with [prolyl-U-</I><SUP>14</SUP>C] <I>DU-1163, which had been prepared from</I> L- [<I>U</I>-<SUP>14</SUP>C] <I>proline and N (S 3-acetylthio-2-methylpropanoyloxy) succinimide. [Prolyl-U</I>-<SUP>14</SUP>C] <I>captopril and [prolyl-U</I>-<SUP>14</SUP>C] <I>DU-1227 were prepared in high yields by hydrolysis of [prolyl-U</I>-<SUP>14</SUP>C] <I>DU-1163 and [prolyl-U</I>-<SUP>14</SUP>C] <I>alacepril, respectively. [Prolyl-U</I>-<SUP>14</SUP>C] <I>captorilcysteine was synthesized by condensation of [prolyl-U</I>-<SUP>14</SUP>C] <I>captopril with cystine S-monoxide in 55.0% yield</I>.
- 社団法人 日本アイソトープ協会の論文
社団法人 日本アイソトープ協会 | 論文
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