Disposition of ipriflavone (TC-80) in rats and dogs.
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<I>Oral</I> <SUP>14</SUP>C-<I>ipriflavone was absorbed by rats to give a maximum plasma</I> <SUP>14</SUP>C <I>level at 1.5h and a half-life of 5.8h. In dogs, after po dosing, the plasma</I> <SUP>14</SUP>C <I>peaked at 0.5h, followed by gradual decline. The plasma of both animals contained mostly metabolites, with small amounts of unchanged ipriflavone. In rats</I>, <SUP>14</SUP>C <I>was distributed widely in tissues, with relatively high concns. in the liver, kidney and gut. Distribution in rat thigh bone of unmetabolized ipriflavone was also demonstrated</I>. <SUP>14</SUP>C-<I>Ipriflavone was eliminated mostly as metabolites within 48 and 72h, respectively, in rats and dogs. Rats excreted more</I> <SUP>14</SUP>C <I>in urine than in feces, whereas the reverse was noted in dogs. Biliary excretion and reabsorption of</I> <SUP>14</SUP>C <I>were also obvious in both animals</I>.
- 社団法人 日本アイソトープ協会の論文
社団法人 日本アイソトープ協会 | 論文
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