<SUP>99<I>m</I></SUP>Tc-2-Mercaptopropionylglycine : Different Biliary Excretion Behavior in Different Animal Species
スポンサーリンク
概要
- 論文の詳細を見る
<I>Labeling of 2-mercaptopropionylglycine (2-MPG) with</I> <SUP>99<I>m</I></SUP>Tc, <I>was studied and its chemical characteristics were examined. Further, biliary excretion behavior of this complex was comparatively estimated in mice, rats and rabbits.</I><BR><SUP>99<I>m</I></SUP>Te-<I>2-MPG was rapidly excreted in large quantities into the bile in mice and rats: within 1 hr after injection, 51% of the injected dose was recovered from the bile in rats. On the other hand, the ligand exchange reaction between this complex and penicillamine indicates that a low hydrolyzed</I> <SUP>99<I>m</I></SUP>Tc <I>species is coordinated with 2-MPG. These results suggest that a low hydrolyzed</I> <SUP>99<I>m</I></SUP>Tc <I>state is an effective feature in biliary excretion behavior of</I> <SUP>99<I>m</I></SUP>Tc <I>compounds.</I><BR><I>Another interesting in vivo behavior of</I> <SUP>99<I>m</I></SUP>Te-<I>2-MPG is the difference observed in mice and rabbits: in mice, very high</I> <SUP>99<I>m</I></SUP>Tc <I>activity is concentrated in the gallbladder and the clearance from tissues other than the gallbladder is rapid, whereas in rabbits, although a apid and high excretion into the gallbladder is observed, a considerable high</I> <SUP>99<I>m</I></SUP>Tc <I>activity is retained in the liver and the kidney. One reason for this different in vivo behavior is the low stability of this complex at high dilution: a big animal has the large dilution volume which lead to higher decomposition estimated by the higher liver and kidney retention or the lower bile excretion.</I><BR><I>In conclusion, studies carried on</I> <SUP>99<I>m</I></SUP>Tc-<I>2-MPG showed a good biliary excretion behavior but an in vivo unstableness in big animals.</I>
- 社団法人 日本アイソトープ協会の論文
社団法人 日本アイソトープ協会 | 論文
- Distortion of Pulse Height Spectra Due to Absorbers in the Measurement of Low-energy .BETA.-rays with a Silicon Detector.
- タイトル無し
- Estimation of Angular Distributions of the Low-Energy .BETA.-Ray Emission from a Sealed Source.
- Comparison of SPECT images with four kinds of 99nTc collimators.
- Cross Talks on to 201Tl- and 123I-Photopeak Windows with Simultaneous Administration of Them, Using of a Gamma Camera.