Indium Labelled Bleomycin (<SUP>111</SUP>In-BLM) as a Tumor Localizing Agent:—A New Method for Quantitative Evaluation for Combined Scintigraphy—
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<I>In a evaluation of</I> <SUP>111</SUP>In-<I>BLM as a tumor-imaging agent, both fundamental and clinical studies were performed</I>.<BR><I>The radiochemical purity of the complex was assayed by paper chromatography and no more than 1.0% of the free radionuclide was recovered. Rf values of</I> <SUP>111</SUP>In-<I>BLM was between 0.7 and 0.9</I>.<BR><I>The in vivo stability of the complex was ascertained by thin-layer-chromatography of urine</I>.<BR><I>The blood clearance, ratio of plasma to whole blood of</I> <SUP>111</SUP>In-<I>BLM and cummulative excretion curves of urine and stool was studied</I>.<BR><I>The blood clearance curve showed that the first half time was 16 minutes and more than 90% of the administered activity was cleared from the circulating blood in two days. Ratios of plasma activity to the whole blood was almost constant in 100 hours after injection</I>.<BR><I>Urinary and fecal excretion showed that 80% of the administered activity was excreted in 24 hours, mainly in the urine and below 1.0% in the feces</I>.<BR><I>There appeared to be an inverse relationship between urinary and fecal excretion. The effective and biological half time of the liver, heart, bone marrow at the level of L</I><SUB>4</SUB> <I>and spleen were obtained by counting activities externally using probes located at each corresponding site</I>.<BR><I>The activity at the bone marrow and heart showed rather short effective half time. The clinical usefulness of</I> <SUP>111</SUP>In-<I>BLM as a tumor imaging agent was evaluated in 19 patients, with 12 malignancy and 7 benign lesions in Mitsui Memorial Hospital. Each study by</I> <SUP>111</SUP>In-<I>BLM was combined with</I> <SUP>67</SUP>Ga-<I>citrate scintigrams</I>.<BR><I>A new method for comparative analyses between two radio pharmaceuticals without using computer was reported here, as comparative evaluation by naked eyes was difficult to determine. Clinical experience to date seems to be encouraging to the detection of malignancy, although some benign tumors showed marked uptake of</I> <SUP>111</SUP>In-<I>BLM</I>.
- 社団法人 日本アイソトープ協会の論文
社団法人 日本アイソトープ協会 | 論文
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