Study on Tumor Affinity of Technetium-99<I>m</I> Labeled Radiopharmaceuticals (2):<SUP>99<I>m</I></SUP>Tc-Sn-Diphosphonate (<SUP>99<I>m</I></SUP>Tc-EHDP), <SUP>99<I>m</I></SUP>Tc-Sn-Dimercaptosuccinic acid (<SUP>99<I>m</I></SUP>Tc-DMSA),
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<I>The authors have examined the tumor affinity of various</I> <SUP>99<I>m</I></SUP>Tc-<I>labelled radio pharma ceuticals to Ehrlieh's tumor for the purpose of delineating positively human malignant neoplasm. This paper includes biologic distributions of</I> <SUP>99<I>m</I></SUP>Tc-Sn-<I>diphosphonate</I> (<SUP>99<I>m</I></SUP>Tc-<I>EHDP</I>), <SUP>99<I>m</I></SUP>Tc-Sn-<I>dimercaptosuccinic acid</I> (<SUP>99<I>m</I></SUP>Tc-<I>DMSA) and</I> <SUP>99<I>m</I></SUP>Tc-Sn-<I>diethyl stilbestrol diphosphate</I> (<SUP>99<I>m</I></SUP>Tc-<I>DSDP</I>, <SUP>99<I>m</I></SUP>Tc-<I>Honvan) as the second report on the tumor affinity to the Ehrlich-bearing mice.</I><BR><I> (a) Tumor concentration of</I> <SUP>99<I>m</I></SUP>Tc-<I>EHDP was lowest and the positive delineation of implanted tumor with</I> <SUP>99<I>m</I></SUP>Tc-<I>EHDP was poorest in sequential images, though the active accumulation to some soft tissue maglinant neoplasms, the breast cancer and the thyroid cancer, has been reported.</I><BR><I> (b) Tumor concentration and tumor to blood ratio of</I> <SUP>99<I>m</I></SUP>Tc-<I>DMSA were not so high on the contrary of our expectation that</I> <SUP>197</SUP>Hg-<I>DMSA may show the high tumor concent-ration and the high tumor to blood ratio like</I> <SUP>197</SUP>Hg <I>ehlormerodrin as same renal scanning radio pharmaceuticals.</I><BR><I> (c) Tumor concentration of</I> <SUP>99<I>m</I></SUP>Tc-<I>DSDP was highest. Tumor to blood concentration ratio, however, was lower than that of the above mentioned radiopharmaceuticals but tumor to liver ratio and/or tumor to lung ratio was over 1.0 at the earlier time. Biologic distribution of</I> <SUP>99<I>m</I></SUP>Tc-<I>DSDP was similar to that of</I> <SUP>32</SUP>P <I>labeled DSDP and then it is presumed that</I> <SUP>99<I>m</I></SUP>Tc <I>is labeled at phosphate ester of DSDP which is dephospholytated immediately by phospholylase in vivo following the intravenous injection. Therefore, it may be assumed that the accumulation mechanism of</I> <SUP>99<I>m</I></SUP>Tc-DSDP <I>to Ehrlich's tumor is related to the phospholylase activity in neoplasms but is not known precisely.</I>
- 社団法人 日本アイソトープ協会の論文
社団法人 日本アイソトープ協会 | 論文
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