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Fundamental and clinical investigation on the liver scanning were carried out with99mTc-Sn-colloid (99mTc-Sn-C) and 99mTc-phytate (99mTc-P), both of which were made into kits by Daiichi Radioisotope Labs., Ltd. for the non-electrolytic method. In the preparing point of view, 99mTc-P seems to be prepared more simple and stable than99mTc-Sn-C. The labelling yields of both agents were about 99% and, also their particle sizes were uniform. In the liver scintigrams, any remarkable differences between both agents were not observed in shape, size, and RI distribution of the liver and any background images disturbing to read the scintigrams were not observed. The splenic image with99mTc-Sn-C was more clearly delineated than that with99mTc-P. Generally, the RI ratio of spleen vs. liver (right lobe) (Sp/R) with99mTc-Sn-C was greater than that with99mTc-P irrespective of each group of liver diseases. Especially, in the liver cirrhosis, Sp/R ratio was remarkably high, and this fact is very important for its scan diagnosis. In the liver scintigrams, the degree of splenic visualization with99mTc-P being quite similar to that with198Au-colloid, the scintigram with99mTc-P seems convenient as diagnostic criteria. In the point of correct diagnosis for liver cirrhosis, 99mTc-Sn-C was superior to99mTc-P. Liver scintigrams obtained with99mTc-Sn-C and99mTc-P respectively are useful for the differential diagnosis of the upper abdominal masses, observation of therapeutic course of various liver diseases, decision on the existence of operative indication and its method. No side effects were observed in both agents, 99mTc-Sn-C and99mTc-P. We came to a conclusion that both99mTc-Sn-C and99mTc-P are effective scanning agents, giving scintigrams of excellent quality with very little internal radiation exposure and fairly simple kit operation.
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社団法人日本アイソトープ協会 | 論文

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社団法人 日本アイソトープ協会 | 論文

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社団法人日本アイソトープ協会 | 論文