Comparison between 57Co-bleomycin, 99mTc-bleomycin and 111In-bleomycin as the Tumor Scanning Agents

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The tumor affinity of 57Co-bleomycin, 99mTc-bleomycin and 111In-bleomycin was examined by using Yoshida sarcoma-bearing rats, and inflammation affinity of these compounds was also tested by rats with inflammation induced by croton oil injection. In our experiments, 57Co-bleomycin had excellent biological characteristics as the tumor scanning agent, but 99mTc-bleomycin and 111In-bleomycin showed poor results compared to 57Co-bleomycin as the tumor scanning agent. All compounds were rapidly excreted in the urine. But retention values of 99mTc-bleomycin and 111In-bleomycin were similar to each of those of 99mTcO-4 and 111In-citrate than those of 57Co-bleomycin. And all compounds had relatively strong affinity to the inflammation tissue. Half a millicurie of 57Co-bleomycin was injected intravenously to twenty-three patients with a variety of known malignancies and scintiphotos were obtained at six and twenty-four hours after injection. Two to three millicurie of 99mTc-bleomycin were injected intravenously to six patients in these twenty-three patients and scintiphoto were obtained at thirty and sixty minutes after injection. In case of 57Co-bleomycin, tumor were positively delineated in fifteen of twenty-three cases, but tumor were not positively delineated in patients administered 99mTc-bleomycin.
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