Clinical Application of 113Sn-113mIn Cow (First Report)

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It is desirable for radioisotope scanning of organs to use the nuclide which gives more photon output while reducing the absorbed radiation dose to the patient. Although 99mTC, a short-lived nuclide is nearly ideal from this point of view, it is not necessarily widely used because of short half life (2.8 days) of parent nuclide 99Mo as well as expensiveness of 99Mo-99mTc cow for its short shelf life of 10 days. 113Sn-113mIn cow is extremely useful in this respect because that 113Sn is a long-lived nuclide (118 day half-life), daughter nuclide 113mIn decays with a half-life of 1.7 hrs. by emitting 390-keV mono-energetic gamma rays (no beta emission) and milking of 113mIn from the cow with dilute HCl can be practiced twice a day. By simple procedure the various-sized particles of 113mIn can be prepared very quickly. The authors followed the radiopharmacological methods reported by H.S. Stern, et al. for lung, liver scanning and besides succeeded in preparing 113mIn-microcolloid (tentatively named) for bone marrow scanning recently. 113mIn is one of the most promising short-lived nuclides and 113Sn-113mIn cow will be widely accepted in future.
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