REDUCTION OF SERUM ANTI HOUSE DUST IGE ANTIBODY DURING DSCG INHALATION THERAPY IN ASTHMATIC CHILDREN

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We examined serum IgE (RIST), house dust specific IgE (RAST) and mite (dermato-phagoides farinae) specific IgE (RAST) in 134 atopic ashtmatic children at the initiation of therapy and one year later. According to their age, they were divided into two groups (<7 years old group and ≥7years old group). Moreover, according to the modality, each group was divided into three groups (DSCG-, theophylline RTC-and no drug group). In theophylline RTC group of <7 years old- and ≥7 years old asthmatic children, IgE (RIST) was reduced significantly. There has been no report that theophylline can reduce IgE production. In DSCG group of ≥7 years old asthmatic children, house dust specific serum IgE (RAST) was reduced from 8.83PRU/ml to 7.49PRU/ml (p<0.05). In other groups, house dust specific IgE (RAST) was not reduced. Kimata et al reported recently that DSCG reduced IgE production in vitro. Our report is the first that DSCG and theophylline are able to reduce IgE production in vivo.
日本小児アレルギー学会の論文