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It is uncertain what level of immunofunction is needed for safe vaccinations. There is no definite guideline regarding this issue. Therefore, we inoculated 3 partial DiGeorge syndrome patients and 2 transient hypogammaglobulinemia of infancy patients; they were vaccinated with BCG vaccine (4 times), polio vaccine (3 times), measles vaccine (3 times), rubella vaccine (3 times) and diphtheria-purified pertussis-tetanus vaccine (15 times) in order to assist making the guideline for vaccinations to immunocompromised patients. The lowest level of CD3 positive T cells before the vaccinations was 49% in the case of measles/rubella vaccine, 47% in the case of BCG/polio vaccine and 33% in the case of diphtheria-purified pertussis-tetanus vaccine. In addition, the lowest level of CD4 positive T cells before the vaccinations was 29% in the case of measles/rubella vaccine, 25% in the case of BCG/polio vaccine and 18% in the case of diphtheria-purified pertussis-tetanus vaccine. Because no severe side effects were recognized after these vaccinations, it suggests safe to vaccinate the immunocompromised patients who keep the above mentioned levels of CD3 positive T cells and CD4 positive T cells.
日本小児アレルギー学会の論文