EFFECT OF DIETARY SUPPLEMENTATION WITH IPAOLE, A HEALTH FOOD ENRICHED WITH N-3 POLYUNSATURATED FATTY ACIDS, IN THE TREATMENT OF ATOPIC DERMATITIS

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We have investigated the effect of supplementing the diet with a health food Ipaole, which is rich in n-3 polyunsaturated fatty acids such as α-linolenic, eicosapentaenoic and docosahexaenoic acids, in the patients with atopic dermatitis. Forteen patients including 8 girls and 6 boys (mean age, 9.5 years; range 4 to 14 years), were given Ipaole for at least 4 weeks before evaluation. The supplementation led to a moderate improvement in cutaneous erythema, itch and overall subjective assessment of severity in six of them, and to the mild improvement in two. However, one patient got worse after treatment. No significant change was observed in the other subjects. The plasma phospholipids eicosapentaenoic acid/arachidonic acid ratio (EPA/AA ratio) was greater than 0.5 in the subjects with clinical improvement, while it differs among the individuals. In conclusion, dietary supplementation with the n-3 polyunsaturated fatty acids may be useful for the treatment of atopic dermatitis in children.
日本小児アレルギー学会の論文