THE EFFECTS OF DISODIUM CROMOGLYCATE ON BRONCHIAL HYPERRESPONSIVENESS IN CHILDREN WITH ASTHMA

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We studied the effects of disodium cromoglycate (DSCG) on bronchial hyperresponsiveness in 38 mild asthmatic children. The subjects were divided into two groups; patients of group D inhaled 20mg of DSCG 3 times daily and group C had no prophylactic drugs. Acetylcholine inhalation challenge test was performed repeatedly before and after 3 months of treatment (10 cases in group D and 14 cases in group C), 6 months (7 in group D, 5 in group C) and 12 months (15 in group D, 10 in group C). Respiratory threshold of acetylcholine (RT-Ach) did not significantly change after 3 months of treatment and slightly increased after 6 months of treatment in both groups. After 12 months of treatment, RT-Ach significantly increased in group D, but did not change in group C. We concluded that long-term use of DSCG decreased the bronchial hyperresponsiveness in asthmatic children. The number of eosinophils in peripheral blood significantly decreased after 1 year of treatment only in group D. From this results, we guess that DSCG might have the effect on eosinophils contributing to the inflammatory process of asthma and protect against the increase of bronchial hyperresponsiveness.
日本小児アレルギー学会の論文