THE RELATIONSHIP BETWEEN BRONCHIAL HYPERRESPONSIVENESS AND SEVERITY AND PROGNOSIS OF BRONCHIAL ASTHMA

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Changes in respiratory resistance (Rrs) upon methacholine inhalation asthmatic children were monitored by "Astograph", and the Rrs were measured by the forced oscillation method. Seventy two cases of asthma, 18 cases of other allergic diseases and 16 cases of healthy adult were subjected to examination for bronchial hyperresponsiveness. The results were as follows:1) Control respiratory condactance (Grs cont) was lower in patiants with bronchial asthma compared with that in healthy adults.2) Methacholine inhalation test showed a higher level of positive rate in severe to mild asthmatics compared with the remission group. And no difference was seen between the remission group and healthy subjects.3) Bronchial sensitivity (Dmin) was lower in severe asthmatics and there was no difference between the remission group and healthy subjects.4) Significant correlation between bronchial sensitivity (Dmin) and duration of no asthmatic symptom was found in patiants with bronchial asthma. These results suggest that continuance of duration of no asthmatic symptom is important in improvement of bronchial hyperresponsiveness.5) There was no difference in bronchial reactivity (SGrs/Grs cont) between the 3 groups.
日本小児アレルギー学会の論文