COMPARISON OF CIRCADIAN VARIATION OF PLASMA CONCENTRATION BETWEEN THEOLONG 50mg AND THEO-DUR 50mg TABLET

概要

論文の詳細を見る
We have investigated the circadian variation of plasma concentration and bioavailability of Theolong 50mg and Theo-dur 50mg tablets at a steady state following dosing at 12-hour intervals comparing 10 asthmatic children using a cross-over method.There was no significant difference in the plasma theophylline level of each time. In the cases of Theolong and Theo-dur, the mean maximum plasma concentration (Cmax) and the area under the curve (AUC) in the night-time were significantly lower than those in the day-time. Peak-trough difference in the day-time was significantly higher than that in the night-time.These results suggest that Theolong and Theo-dur 50mg tablets have the same circadian variation and bioavailability as those in Theolong and that Theo-dur 100 or 200mg tablets and these drugs were useful for younger children because of their small size. But it was necessary to administer a higher dose of theophylline in the night-time compared with that in the day-time.
日本小児アレルギー学会の論文