INVESTIGATION CONCERNING THE MOST SUITABLE METHOD OF METERED DOSE INHALER (MDI) OF β-STIMULANT.: (1) HOW TO TAKE MDI IN MOUTH AND ITS POSITION

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Twenty-four children aged from 8-14 (ave. 10.4y) who have bronchial asthma in children, inhaled MDI by three different methods. And then we observed flow volume curve, spirogram, and clinical symptoms of the patients. This study tested in three groups cross-over design, in 13 clinical centers.The three inhaling methods are as follows:group I: Patients keep MDI 4cm away from their mouths and inhale with widely open mouths.group II: Patients take its adapter between their teeth and inhale with widely open mouths.group III: Patients hold its adapter between their lips and inhale with closed mouth.The result of this experiment is that the inhaling method with the lower efficacy is group III compared with group I and II. Then comparing these groups, group II is obiously more effective than group I.Therefore in conclusion, the most effective method of MDI for childhood asthma is to take adapter between teeth and inhale with widely open mouth.
日本小児アレルギー学会の論文