EFFECTS OF OXATOMIDE ON BRONCHIAL HYPERRESPONSIVENESS IN CHILDHOOD ASTHMA

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By double-blind, placebo-controlled method we have investigated the effect of oxatomide on bronchial hyperresponsiveness in 9 asthmatic children, using methacholine inhalation challenge test. After premedication of 0.88mg/kg oxatomide or placebo, the challenge test was performed.Respiratory thresholds were improved in 7 cases and PC20 became significantly higher in the case of premedication of oxatomide.Since oxatomide has no appreciable anticholinergic effect this observation is an indication that oxatomide decreases non-specific bronchial hyperreactivity. This improvement of bronchial hyperresponsiveness might be ascribed to its inhibitory action on synthesis and release as calcium antagonists and to the antagonistic activity of various chemical mediators, particularly leukotrienes and PAF; moreover, to its effect on β-receptors.
日本小児アレルギー学会の論文