CHANGES IN LYMPHOCYTE SUBPOPULATION FOLLOWING ANESTHESIA AND OPERATION

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Immunity is often influenced by anesthesia and operation, We investigated the peripheral lymphocyte subpopulation before and after general anesthesia. The lymphocyte subpopulation (CD3, CD4 and CD8) were measured in 29 children before the anesthesia and the day after, CD3, CD4 and CD8 positive lymphocyte decreased when patients had been taken the surgery operation for the anesthesia more than several hours. We also measured the peripheral lymphocyte subpopulation (Thy1.2, Lyt-2 and L3T4) in mice in order to clarify whether immunity was influenced by anesthesia or by operation. As the result, Thy1.2+ Lyt-2+ and L3T4+ lymphocyte decreased after anesthesiaThese results suggested that the number of lymphocyte is mainly influenced by anesthesia.Plasma histamine levels in patients also increased from 0.12±0.04ng/ml to 0.22±0.13ng/ml after intravenous injection of atoropine sulfate and pancuronium.
日本小児アレルギー学会の論文