STUDIES ON ADRENOCORTICAL FUNCTION IN TEN CHILDREN WITH SEVERE ATOPIC DERMATITIS

概要

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We examined adrenocortical function in ten children with severe atopic dermatitis who were treated with topical corticosteroid preparations for an average of 4 years and 11 months.The ACTH stimulation test was performed with an intravenous drip of ACTH (0.003mg/kg in one hour). Observation was carried out 2 hours later. A rising incline index in cortisol or 11-OHCS per hour was used.In children with atopic dermatitis, the rising incline index was significantly smaller than in control patients who did not receive prolonged topical corticosteroid therapy (p<0.01). No differences in basal cortisol or 11-OHCS levels were noted. For 4 patients, their heights were less than -2 SD.The results suggest that topical corticosteroid therapy for atopic dermatitis may cause adrenal suppression and also stunted growth and a permanent short stature. The mode of topical therapy shoud be changed to alternating or daily administration in the morning in patients with insufficient responsiveness to ACTH stimulation.
日本小児アレルギー学会の論文