:EXAMINATION OF PLASMA CONCENTRATIONS OF DISODIUM CROMOGLYCATE ADMINISTERED BY METERED-DOSE INHALER WITH AND WITHOUT SPACER DEVICE

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We examined plasma concentrations of disodium cromoglycate (DSCG) in 16 children and adolescents with asthma inhaled 2mg (2puffs) of DSCG using MDI by 3 different methods; Aerosol method: 2puffs without a large volume spacer (Fisonair), Usual method: 2 times of 1 inhalation with Fisonair after single puff, and Simple method: 1 time of 1 inhalation with Fisonair after 2 puffs. The mean plasma concentrations of DSCG at 5 minutes and 30 minutes after inhalation and AUC0-30 in Usual method were higher than those in Aerosol and Simple methods. Multiple actuations into the spacer (Simple method) was not so effective to increase plasma concentrations of DSCG as individual actuation (Usual method). The plasma concentration of DSCG at 5 minutes after inhalation (C5) exceeded 4ng/ml, which was reported to be more effective to protect asthmatic attacks, in half the number of patients in Usual and Simple methods. We suggest that drug dose delivered to the lung and protective efficacy of DSCG aerosol for asthmatic attacks might be increased by inhalation of DSCG with Fisonair.
日本小児アレルギー学会の論文