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We examined plasma concentrations of disodium cromoglycate (DSCG) on 6 healthy adults skilled with inhalation therapy using 3 types of nebulizer (NE-U07 as a formal type of ultrasonic nebulizer, NE-U14 as a handy type of ultrasonic nebulizer, and Voyage as a compressed air nebulizer) to estimate differences of drug amounts accessible to the lung among three types of nebulizers. The mean plasma concentration of DSCG by NE-U07 was the highest and that by Voyage was the lowest at any times after inhalation. The mean Area Under the Curve up to 480 min after inhalation was 2197.46min·ng/ml by NE-U07, and 1170.59min·ng/ml by NE-U14, but by Voyage, it was 441.10min·ng/ml, which was lower than that by NE-U07 significantly (p=0.03). Plasma concentration of DSCG exceeded 4ng/ml, which was reported to be more effective to protect asthmatic attacks, in all subjects using NE-U07, in almost half numbers of subjects using NE-U14, but in only one subject using Voyage. We estimated that the amount of DSCG accessible to the lung using ultrasonic nebulizers might be more than that using a compressed air nebulizer. Moreover, the formal type of ultrasonic nebulizer showed the possibility to obtain larger amount of DSCG accessible to the lung than the handy type of ultrasonic nebulizer.
日本小児アレルギー学会の論文