:COMPARISON BETWEEN L- AND DL- ISOPROTERENOL

概要

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In Japan, it has been known that the continuous isoproterenol inhalation therapy is effective for children with severe asthma attack. There are two types of prescribed isoproterenol; single enantiomer (l-isoproterenol) and a racemic drug (dl-isoproterenol). We sought to compare effectiveness of l-isoproterenol with equivalent amount of l-isoproterenol administered as a racemic drug. One hundred and six children with severe asthma attack were randomly assigned to the inhalation with l-(n=65) or dl-isoproterenol (n=41). There was no difference in their backgrounds between two groups. To evaluate the effectiveness of these drugs, we assessed Wood's clinical score, oxygen saturation, heart rate, and respiratory rate. Improvement of Wood's clinical score and tachycardia by l-isoproterenol was more prominent compared with dl-isoproterenol during the first 6-hour of inhalation. Although all the patients treated with l-isoproterenol improved, three out of 41 children did not respond well to dl-isoproterenol. These results suggest that l-isoproterenol appears to provide a better therapeutic effect than dl-isoproterenol.
日本小児アレルギー学会の論文