Clinical evaluation of recurrent lower respiratory tract infection caused by penicillin-resistant Streptococcus pneumoniae in children with bronchial asthma

概要

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Infection is one of the important causative factors of asthmatic attack. We examined the clinical features of eight children with bronchial asthma who had recurrent lower respiratory tract infection caused by penicillin-resistant Streptococcus pneumoniae. Asthma was severe in all the subjects, according to the criteria of the Japanese Research Group for Pediatric Allergy.Two of them had IgE antibodies specific to house dust and mites antigens. Immunological examination showed that all children were deficient in IgG2 subclass antibodies to pneumococcal capsular polysaccharides and one had IgA deficiency. Five children were treated chronically with low- dose erythromycin therapy.This tratment regimen reduced the frequncy of asthmatic attack in four of them.
日本小児アレルギー学会の論文