EXAMINATION OF ABSORPTION RATES OF SUSTAINTED RELEASE THEOPHYLLINE PREPARATION AND AMINOPHYLLINE ON THE DETERMINATION OF THEOPHYLLINE IN FACES
スポンサーリンク
概要
- 論文の詳細を見る
In case of infants, it has been known that residence time in the digestive tract is shortier than in case of adults with the result that sustained-release preparations are not necessarily absorbed a hundred percent and that a serum concentration varies with the type of preparations and patient's conditions, thus causing a change in AUC (area under the curve). However, while theophylline absorption rates have so far been determined on the basis of determination of a total amount of metabolites in urine or determination of a change of its serum concentration.When a quotient obtained by dividing an amount of theophylline excreted feces by a dose of theophylline was taken as a theophylline excretion rate in feces, the cxcretion rate was 1% or below for aminophylline, 2% or below for Theolong (excluding onf case of bad fecal nature), 3% of below for The odor, 4% or below for Slobid (excluding 3 cases), and 12% at a maximum.A theophylline concentration in feces was 7.0±9.57μg/g after administration of aminophylline, 26.8±42.5μg/g after administration of Theolong, 19.9±12.3μg/g after administration of Theodur, and 54.3±43.4μg/g (Mean±SD) after administration of Slobid.The above has made it known that sustained-release theophylline preparations are not necessarily absorbed hundred percent and that there is a difference in absorption between types of preparations. In determination of a serum theophylline levels, especially when said concentration is low, in addition to a case of a large clearance and is a case in which absorption is not sufficient due to too short residence time in the intestines and bioavailability is low.
- 日本小児アレルギー学会の論文
日本小児アレルギー学会 | 論文
- IMPROVED METHOD OF MEASRUING EXHALED NITRIC OXIDE (NO)
- タイトル無し
- タイトル無し
- タイトル無し
- INVESTIGATION ON THE USEFULNESS OF SPACER DEVICE FOR INHALATION OF:β2-STIMULANT WITH MDI IN ASTHMATIC CHILDREN