SEVEN CASES OF CHILDREN WITH SEIZURES AND NEUROLOGIC SYMPTOMS DURING THEOPHYLLINE ADMINISTRATION

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Seven cases of children who had seizures or neurologic symptoms during theophylline administration were reported. One patient was treated with overdose theophylline preparation, but the rest of the patients were treated with appropriate doses. These patients were classified into two cases of encephalopathy, one case of induced epileptic seizure, two cases of induced febrile convulsion, and two cases of theophylline intoxication. The theophylline-associated seizures shared tendencies to have long duration and to be refractory to various anticonvulsants. One of two patients with encephalopathy had an unilateral brain damage, the other patient had a long stupor status. The patients with theophylline intoxication had many symptoms prior to seizures including vomiting, sleep disturbance and headache, whereas other cases had few preceding symptoms. Theophylline administration to the patients with a history of seizures should be carefully done, because it has a possibility to develop seizures even under the toxic level. Furthermore, to avoid theophylline intoxication, it is important to pay attention to various preceding symptoms.
日本小児アレルギー学会の論文