INVESTIGATION CONCERNING THE MOST SUITABLE METHOD OF β-STIMULANT:THE TIME INTERVAL BETWEEN PUFFS, AND DIFFERENCE OF 10μg OF PROCATEROL AS A SINGLE INHALATION AND TWO INHALATIONS OF 5μg

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We examined clinical symptoms and the changes of the MEFV curve under the conditions of different time interval between puffs in asthmatic children, who inhaled β-stimulant with MDI. A total of 23 subjects were studied. There was no significant difference between either mode of inhalation.In the second trial, we also examined the effects of number of inhalations on changes of clinical symptoms and those of the MEFV curve in asthmatic children in the same manner. 18 subjects were studied. There was no significant difference between 10μg of procaterol as a single inhalation and two inhalations of 5μg.These results suggest that instruction for the optimal inhalation of β-stimulant MDI in children is to be no need to recommend pauses between the puffs, and a single inhalation may be sufficient to deliver the required dose to obtain an effective response.
日本小児アレルギー学会の論文