RESERCH ON LEVELS OF IgG SUBCLASS IN ALLERGIC CHILDREN (SECOND REPORT):THE FLUCTUATION DEPEND ON AGING OF SERUM LEVELS OF IgG2 AND IgG3 IN CHILDREN WITH BRONCHIAL ASTHMA

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We reported that 13.7% of allergic children showed low levels of concentration of at least one of IgG subclass in first report. In this report we represented the fluctuation depend on aging of IgG subclass in the patient with bronchial asthma. The subjects were 8 patients who showed low level in IgG2 or IgG3 and 10 patients who showed normal level in IgG2 or IgG3.The fluctuations of IgG2 in the patients with normal IgG2 and IgG3 in the patients with normal IgG3 were limited in normal ranges in all cases. One of 3 cases who showed low IgG2 represented increasing in IgG2 level by aging. The level of IgG2 in other 2 cases who showed low IgG2 level increased to the normal level temporally and became lower level by aging again.The concentrations of IgG3 became in to the normal level in 4 out of 6 cases who showed low IgG3. Other 2 cases remained in the low levels by aging. Three cases out of 4 cases who showed normalization represented the low level which belong to be in the normal range. Accordingrange. According to these results we concluded that some of patients with bronchial asthma showed low levels in IgG2 or IgG3 for long time.
日本小児アレルギー学会の論文